Continued versus discontinued oxytocin stimulation in the active phase of induced labour: Factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial.

Objective: To examine the factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial of continuation versus discontinuation of oxytocin infusion during induced labour. Design: Secondary retrospective analysis of data from a prospective randomised controlled trial. Setting Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020. Population or sample: 1200 women having labour induced. Methods: Analysis of outcomes by actual management. Main outcome measures: Mode of delivery and associated variables. Results: Switching to open label oxytocin (42.4% overall) was associated with nulliparity, an unripe cervix, larger babies and higher rates of delivery by caesarean section. Conclusions: In the CONDISOX trial, slow labour was associated with features suggesting a higher 'resistance to progress', often prompting the use of open‐label oxytocin infusion rather than study medication. Linked article: This article is commented on by G. J. Hofmeyr, pp. 643–644 in this issue. To view this mini commentary visit https://doi.org/10.1111/1471‐0528.17377. [ABSTRACT FROM AUTHOR]