Yenidoğanlarda seftriakson kullanımının yan etkilerinin değerlendirilmesi.

Purpose: Ceftriaxone is used sparingly in newborns due to its side effects. There are limited studies about its use in neonatal infections. In this study, it was aimed to evaluate the side effects that may occur after ceftriaxone therapy in newborns. Materials and Methods: The clinical and laboratory data before (baseline) and after ceftriaxone treatment of newborns hospitalized in the Newborn Intensive Care Unit of Cukurova University Medical Faculty, Balcalı Hospital between 2015 - 2016 were retrospectively analyzed. Results: Thirty cases were included in the study. The mean gestational age of these babies was 37 ± 3.1 (30-41) weeks, and mean duration of ceftriaxone treatment was 7.2 ± 2.2 (2-12) days. Urine cultures were obtained from all patients and microorganism growth was detected in 17 (56.6%) infants. Escherichia coli grew in 11 (36.6%) cultures while other bacteria were identified in 5 (16.7%) cases. Compared to baseline, significant decreases were found in blood urea nitrogen, total bilirubin and hematocrit values after ceftriaxone therapy. No side effects related to the use of ceftriaxone were observed. Conclusion: The fact that no complications were observed after ceftriaxone in our study may be encouraging, both for the use of ceftriaxone in term or near-term newborns and for conducting extensive studies. More research is needed to investigate the side effects of ceftriaxone in newborns and to determine whether it can be an alternative to other antibiotics. [ABSTRACT FROM AUTHOR]