Influence of urea/glucose on the mixed micellization behavior of amitriptyline hydrochloride and 1-hexadecyl-3-methylimidazolium chloride (ionic liquid) mixtures: An experimental and theoretical investigation.

• Interaction of amitriptyline hydrochloride (AMT) with ionic liquid were studied. • Clint, Motomura, Rubingh, Rosen, etc. hypothetical models were used. • Activity coefficients were found below one, exhibiting interactions amongst constituents. • FTIR/UV–visible spectroscopy was also used to estimate interactions amid components. • Current results show that ionic liquid possibly will be effective drug delivery vehicle. Mixtures of an antidepressant drug, amitriptyline hydrochloride (AMT), and ionic liquid, 1-hexadecyl-3-methylimidazolium chloride (HMICl), were investigated by tensiometry at a temperature of 298.15 K with diverse mole fraction (α 1) of HMICl to determine the association, surface, and thermodynamic properties. Fourier transform infrared (FTIR) and UV–visible spectroscopy were also used to estimate the interactions between AMT and HMICl. AMT can treat depression, anxiety, and other mental illnesses. Imidazolium-based surface-active ionic liquids are ideal for biomedical uses because of their unique physicochemical properties. The interaction between AMT and HMICl was also examined using non-aqueous solvent systems (500 mmol·kg−1 urea and 250 mmol·kg−1 glucose). The ideal cmc (cmc id) measured for the mixed system (AMT + HMICl) tensiometry was notably smaller than the critical micelle concentration (cmc). As a result, AMT and HMICl interact fairly well, and interaction also increased when the α 1 of HMICl increased. The cmc values for pure and mixed solutions in urea were higher than those in aqueous, while in glucose, they were lower. Hypothetical models, including those of Clint, Motomura, Rubingh, and Rosen, have been used to determine the association, interfacial, and thermodynamic properties. For each constituent, the activity coefficients were consistently < 1 for micellar along with interface, exhibiting the intermolecular interactions amongst constituents as well as nonideal behavior. The excess free energy was negative in each case, implying that mixed micelles and monolayers have higher stability than micelles and monolayers of single components. The direct interaction of AMT and HMICl was also characterized by FTIR and UV–visible analysis, similar to the tensiometric method. In summary, the ionic liquid HMICl may be an effective drug delivery vehicle. [ABSTRACT FROM AUTHOR]