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Regioselective Alkynylation of Allylic Phosphates with Alkynyl Copper Reagents.
- Source :
-
European Journal of Organic Chemistry . 4/6/2023, Vol. 26 Issue 14, p1-5. 5p. - Publication Year :
- 2023
-
Abstract
- We developed an alkynylation of allylic phosphates with acetylenes in the presence of copper and magnesium salts. The reaction proceeded regioselectively to afford the corresponding 1,4‐enynes. Furthermore, the functional group tolerance of this reaction was established. As an application, the 1,4‐enyne intermediate involved in the synthesis of 13R,19S,20S‐trihydroxydocosapentaenoic acid could be efficiently synthesized. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOSPHATES
*COPPER
*COPPER salts
*REGIOSELECTIVITY (Chemistry)
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 1434193X
- Volume :
- 26
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- European Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 162971697
- Full Text :
- https://doi.org/10.1002/ejoc.202300056