Back to Search
Start Over
Sulfoxide-Containing Bisabolane Sesquiterpenoids with Antimicrobial and Nematicidal Activities from the Marine-Derived Fungus Aspergillus sydowii LW09.
- Source :
-
Journal of Fungi . Mar2023, Vol. 9 Issue 3, p1-15. 15p. - Publication Year :
- 2023
-
Abstract
- Phytopathogens, such as phytopathogenic bacteria, fungi, and nematodes, have caused great losses of crops every year, seriously threatening human health and agricultural production. Moreover, marine-derived fungi are abundant sources of structurally unique and bioactive secondary metabolites that could be potential candidates for anti-phytopathogenic drugs. One new sulfoxidecontaining bisabolane sesquiterpenoid aspersydosulfoxide A (1) and nine known analogues (2-10) were isolated from the marine-derived A. sydowii LW09. The absolute configuration of the sulfur stereogenic center in 1 was determined by electronic circular dichroism (ECD) calculations. Compound 5 showed inhibition activity against Pseudomonas syringae, with a minimum inhibitory concentration (MIC) value of 32 µg/mL, whereas, compounds 2, 7, and 8 showed antibacterial activities toward Ralstonia solanacarum, with the same MIC value at 32 µg/mL. Meanwhile, compounds 3, 7, and 8 inhibited the fungal spore germination of Fusarium oxysporum, with the half maximal effective concentration (EC50) values of 54.55, 77.16, and 1.85 µg/mL, respectively, while compounds 2, 3, 7, and 8 inhibited the fungal spore germination of Alternaria alternata, which could be induced by vacuolization of germ tubes, with EC50 values of 34.04, 44.44, 26.02, and 46.15 µg/mL, respectively. In addition, compounds 3, 7, and 8 exhibited nematicidal activities against Meloidogyne incognita secondstage juveniles (J2s). In addition, compound 8 possessed the strongest nematicidal activity of nearly 80% mortality at 60 h with the half lethal concentration (LC50) values of 192.40 µg/mL. Furthermore, compounds 3, 7, and 8 could paralyze the nematodes and then impair their pathogenicity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2309608X
- Volume :
- 9
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Fungi
- Publication Type :
- Academic Journal
- Accession number :
- 162964205
- Full Text :
- https://doi.org/10.3390/jof9030347