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APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.
- Source :
-
Science Advances . 4/7/2023, Vol. 9 Issue 14, p1-10. 10p. - Publication Year :
- 2023
-
Abstract
- The article presents animal studies suggesting that the apolipoprotein E ε4 (APOEε4) allele as a culprit of early microglial activation in Alzheimer's disease (AD). It mentions the testing of the association between APOEε4 status and microglial activation in living individuals across the aging and AD spectrum.
- Subjects :
- *NEUROFIBRILLARY tangles
*MICROGLIA
*ALZHEIMER'S disease
Subjects
Details
- Language :
- English
- ISSN :
- 23752548
- Volume :
- 9
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Science Advances
- Publication Type :
- Academic Journal
- Accession number :
- 162929769
- Full Text :
- https://doi.org/10.1126/sciadv.ade1474