Obtención y evaluación de matrices hidrofílicas para liberación prolongada de metformina.

Introduction: Diabetes mellitus is a metabolic disorder with a high incidence worldwide, however, treatment with conventional release tablets entails the presence of adverse effects, as well as high and repeated doses. Modified release dosage forms improve the performance of drugs and adherence to therapy by patients, which is why they are a useful alternative in the treatment of diabetes. Aim: To manufacture and to evaluate hydrophilic matrices of metformin hydrochloride using low proportions of HPMC with high viscosity, to obtain tablets that fulfill the prolonged release criteria of United States Pharmacopeia (USP). Methods: Tablets were manufactured by wet granulation and characterized by various pharmacopeial tests including in vitro release studies, with which the release mechanism was studied by fitting mathematical models of Higuchi, Korsmeyer-Peppas and Hixson-Crowell. Results: Formulation F2 complied with the pharmacopoeial quality tests and complied with the acceptance criteria for USP prolonged release criteria, by means of Fick-type diffusion. Conclusions: Hydrophilic matrices for modified release of Metformin were obtained, using low proportions of HPMC as a possible platform for new formulations in the treatment of diabetes. [ABSTRACT FROM AUTHOR]