Convenient preparation of optically active N,N-bis(4-substituted-4-aminobutyl)amines

Abstract: An efficient and convenient method for the synthesis of chiral triamines with two substituents at the α position to the terminal amino group (spermidine analogues) is described. These chiral N,N-bis(4-substituted-4-aminobutyl)amines may have anticancer activities. [Copyright &y& Elsevier]