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Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs.

Authors :
Li, Xuewei
Liu, Weimin
Zheng, Xiuli
Jiang, Meiyu
Guo, Yimin
Sha, Jie
Wu, Jiasheng
Ren, Haohui
Gao, Honglei
Wang, Shuai
Wang, Pengfei
Source :
Chemical Communications. 4/11/2023, Vol. 59 Issue 28, p4181-4184. 4p.
Publication Year :
2023

Abstract

Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
59
Issue :
28
Database :
Academic Search Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
162899328
Full Text :
https://doi.org/10.1039/d2cc07025a