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Lipid droplet targeting-guided hypoxic photodynamic therapy with curcumin analogs.
- Source :
-
Chemical Communications . 4/11/2023, Vol. 59 Issue 28, p4181-4184. 4p. - Publication Year :
- 2023
-
Abstract
- Two photosensitizers (CCOH and CCN) were designed and synthesized by introducing coumarin into the curcumin (CUR) structure. Compared with CUR, more reactive oxygen species (ROS) were generated by CCOH and CCN in type I and II synergy upon light irradiation. Cell experiments indicated that CCN with an excellent LD-targeting effect could be used to monitor the changes in the morphology and number of LDs in tumor cells during PDT. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PHOTODYNAMIC therapy
*CURCUMIN
*REACTIVE oxygen species
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 59
- Issue :
- 28
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 162899328
- Full Text :
- https://doi.org/10.1039/d2cc07025a