Influence of Ranunculus acris Flower Extract on Allium cepa Root Meristem.

The plant Ranunculus acris (L.) is widespread. It is used in folk medicine. The use of herbal medicines can have adverse effects on humans and requires studies of herbal raw materials for genotoxicity. The goals of the study were to examine the toxic and genotoxic effects of aqueous solutions of R. acris flowers at concentrations of 0.625%, 1.25%, 2.5%, 5% and 10% using the Allium test and to determine the numbers of flavonoids and polyphenols and the antioxidant activity of the extracts. It has been shown that aqueous solutions of buttercup flower extract have a depressing effect on mitosis in the cells of the root meristem of Allium cepa (L.) and cause chromosomal abnormalities (chromosomal stickiness, chromosome lagging, nuclear buds and bridges in anaphase). [ABSTRACT FROM AUTHOR]