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A Convenient Diels-Alder Approach toward Potential Polyketide-like Antibiotics Using α-Activated α,β-Unsaturated 4,4-Dimethyl-1-tetralones as Dienophiles.
- Source :
-
Molecules . Mar2023, Vol. 28 Issue 6, p2739. 13p. - Publication Year :
- 2023
-
Abstract
- Making use of a Diels–Alder approach based on various α,β-unsaturated 2-carbomethoxy-4,4-dimethyl-1-tetralones as novel dienophiles, the corresponding polycyclic adducts could be efficiently synthesized in good to high yields (74~99%) in the presence of Lewis acid (e.g., SnCl4). Accordingly, a synthetically useful platform is established to provide a focused aromatic polyketide-like library for screening of potential natural and non-natural antimicrobial agents. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DIENOPHILES
*LEWIS acids
*ANTIBIOTICS
*ANTI-infective agents
*POLYKETIDES
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 28
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 162785033
- Full Text :
- https://doi.org/10.3390/molecules28062739