The role of myeloid-derived immunosuppressive cells in cardiovascular disease.

• Previous studies have focused more on the role of MDSCs in diseases such as tumors, and this review comprehensively summarizes the role of MDSCs in the field of cardiovascular diseases. • The latest literature was reviewed to describe the source, phenotype, and immunosuppressive function of MDSCs. • Comprehensively summarizes the research progress of MDSCs in common cardiovascular diseases such as atherosclerosis, acute coronary syndrome, hypertension, myocarditis, heart failure, and dilated cardiomyopathy. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population found in the bone marrow, peripheral blood, and tumor tissue. Their role is mainly to inhibit the monitoring function of innate and adaptive immune cells, which leads to the escape of tumor cells and promotes tumor development and metastasis. Moreover, recent studies have found that MDSCs are therapeutic in several autoimmune disorders due to their strong immunosuppressive ability. Additionally, studies have found that MDSCs have an important role in the formation and progression of other cardiovascular diseases, such as atherosclerosis, acute coronary syndrome, and hypertension. In this review, we will discuss the role of MDSCs in the pathogenesis and treatment of cardiovascular disease. [ABSTRACT FROM AUTHOR]