Retinoic Acid and Retinoid X Receptors.

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution EN nuclear receptor signaling retinoic acid receptor retinoid X receptor pharmacology structure/function relationships genomic and non-genomic signaling post-translational modification homeostasis and disease development origin and evolution 864 5 03/31/23 20230315 NES 230315 One of the most fundamental discoveries in human biology was that of the existence of essential micronutrients that the body cannot synthesize but nonetheless requires for proper functioning [[1]]. Nuclear receptor signaling, retinoic acid receptor, retinoid X receptor, pharmacology, structure/function relationships, genomic and non-genomic signaling, post-translational modification, homeostasis and disease, development, origin and evolution Only several decades later, all I trans i retinoic acid (RA) was identified as the biologically active metabolite of vitamin A, mediating the observable effects of vitamin A on cell growth and differentiation [[6]]. The intracellular receptor that transduces the signal conveyed by the presence of RA into a cellular response was finally discovered in 1987: the retinoic acid receptor (RAR or NR1B) [[8]]. [Extracted from the article]