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A case of Kleine–Levin syndrome arising during chemotherapy: efficacy of oral L-carnitine.

Authors :
Furihata, Ryuji
Endo, Daisuke
Nagaoka, Kenichi
Hori, Ayako
Ito, Tatsuya
Chin, Kazuo
Akahoshi, Toshiki
Source :
Sleep & Biological Rhythms. Apr2023, Vol. 21 Issue 2, p257-260. 4p.
Publication Year :
2023

Abstract

A woman in her 50 s with Kleine–Levin syndrome (KLS) was referred to our sleep clinic for recurrent episodes of sleep hypersomnia lasting for two to 3 days, despite attempts to remain awake. These episodes were unaccompanied by anxiety or depression, increased appetite, increased sex drive, irritability, or hallucinations, and had first appeared during chemotherapy for malignant lymphoma. Video polysomnography revealed mild obstructive sleep apnea syndrome (apnea–hypopnea index 7.9/h), but no other abnormalities. All blood tests and brain imaging investigations, including brain MRI and A 123I-ioflupane SPECT, yielded normal results. Oral L-carnitine was found to be effective for shortening the period of hypersomnolence, reducing the degree of hypersomnolence, and prolonging the inter-episode period. Since it has been reported that alkylating agents may induce carnitine deficiency, the present observations appear to support the involvement of carnitine in the onset of KLS. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14469235
Volume :
21
Issue :
2
Database :
Academic Search Index
Journal :
Sleep & Biological Rhythms
Publication Type :
Academic Journal
Accession number :
162727354
Full Text :
https://doi.org/10.1007/s41105-022-00434-0