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Static and Dynamic: Evolving Biomaterial Mechanical Properties to Control Cellular Mechanotransduction.

Authors :
Xie, Wenyan
Wei, Xi
Kang, Heemin
Jiang, Hong
Chu, Zhiqin
Lin, Yuan
Hou, Yong
Wei, Qiang
Source :
Advanced Science. 3/24/2023, Vol. 10 Issue 9, p1-37. 37p.
Publication Year :
2023

Abstract

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to mechanobiology is provided. A biophysical perspective on the state‐of‐the‐art manipulation techniques and novel materials in designing static and dynamic ECM‐mimicking biomaterials is taken. In particular, different static and dynamic mechanical cues in regulating cellular mechanosensing and functions are compared. This review to benefit the development of engineering biomechanical systems regulating cell functions is expected. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
21983844
Volume :
10
Issue :
9
Database :
Academic Search Index
Journal :
Advanced Science
Publication Type :
Academic Journal
Accession number :
162673693
Full Text :
https://doi.org/10.1002/advs.202204594