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Sydnone‐Cyanines as Clickable Probes for Fluorescent Labelling.
- Source :
-
Helvetica Chimica Acta . Mar2023, Vol. 106 Issue 3, p1-8. 8p. - Publication Year :
- 2023
-
Abstract
- The synthesis of four clickable sydnone‐heptamethine cyanine derivatives is described in this article. The synthetic route is based on a palladium‐cross coupling reactions of sydnone boronates affording the desired sydnone‐cyanine conjugates in only five steps. These compounds were shown to react smoothly with cyclooctynes to form the corresponding pyrazoles clicked products quantitatively at room temperature and with rate constants up to 18 m−1 ⋅ s−1, affording interesting new tools for biorthogonal fluorescent labelling of (bio)molecules. Fluorescence properties of both sydnone‐ and pyrazole‐cyanines are described, as well. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FLUORESCENT probes
*CYANINES
*PYRAZOLES
*CLICK chemistry
*FLUORESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 0018019X
- Volume :
- 106
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Helvetica Chimica Acta
- Publication Type :
- Academic Journal
- Accession number :
- 162643838
- Full Text :
- https://doi.org/10.1002/hlca.202200187