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The healing effects of thymoquinone on experimentally induced traumatic tendinopathy in rabbits.
- Source :
-
Journal of Orthopaedic Surgery & Research . 3/23/2023, Vol. 18 Issue 1, p1-9. 9p. - Publication Year :
- 2023
-
Abstract
- Objectives: Thymoquinone is a major bioactive compound present in the black seeds of the Nigella sativa. Tendon injuries are almost 50% of all musculoskeletal injuries. The recovery of tendon after surgery has become a significant challenge in orthopedics. Design: The purpose of this study was to investigate the healing effect of thymoquinone injections in 40 New Zealand rabbits tendon traumatic models. Materials and methods: Tendinopathy was induced by trauma using surgical forceps on the Achilles tendon. Animals were randomly divided into 4 groups: (1) normal saline injection (control), (2) DMSO injection, (3) thymoquinone 5% w/w injection, and (4) thymoquinone 10% w/w injection. Forty-two days after surgery, biochemical and histopathological evaluations were done, and biomechanical evaluation was conducted 70 days after surgery. Results: Breakpoint and yield points in treatment groups were significantly higher compared to control and DMSO groups. Hydroxyproline content in the 10% thymoquinone receiving group was higher than all groups. Edema and hemorrhage in the histopathological evaluation were significantly lower in the thymoquinone 10% and thymoquinone 5% receiving groups compared to control and DMSO groups. Collagen fibers, collagen fibers with fibrocytes, and collagen fibers with fibroblasts were significantly higher in the thymoquinone 10% and thymoquinone 5% receiving groups compared to control groups. Conclusions: Thymoquinone injection in the tendon in the concentration of 10% w/w is a simple and low-cost healing agent that could enhance mechanical and collagen synthesis in traumatic tendinopathy models in rabbit. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EDEMA prevention
*HEMORRHAGE prevention
*WOUND healing
*BIOLOGICAL models
*BIOCHEMISTRY
*COLLAGEN
*MEDICINAL plants
*INJECTIONS
*DIMETHYL sulfoxide
*FIBROBLASTS
*BENZOQUINONES
*ACHILLES tendinitis
*ANIMAL experimentation
*ANTI-inflammatory agents
*RABBITS
*POSTOPERATIVE care
*COMPARATIVE studies
*DESCRIPTIVE statistics
*HISTOLOGICAL techniques
*PROLINE
*RESEARCH funding
*PLANT extracts
*STATISTICAL sampling
*BIOMECHANICS
*PHYSIOLOGIC salines
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1749799X
- Volume :
- 18
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Journal of Orthopaedic Surgery & Research
- Publication Type :
- Academic Journal
- Accession number :
- 162638823
- Full Text :
- https://doi.org/10.1186/s13018-023-03706-8