Exposure to a rotating magnetic field as a method of increasing the skin permeability of active pharmaceutical ingredients.

[Display omitted] • The permeability of drugs was investigated in the presence of a rotating magnetic field (RMF). • The RMF may increase the permeability of active pharmaceutical ingredients (APIs). • The enhancement of API permeation through the skin in the presence of RMF depends on the type of API used (variable diffusion profiles). The paper presents a method of increasing the permeability of various active substances through the skin by means of a rotating magnetic field. The study used 50 Hz RMF and various active pharmaceutical ingredients (APIs) such as caffeine, ibuprofen, naproxen, ketoprofen, and paracetamol. Various concentrations of active substance solutions in ethanol were used in the research, corresponding to those in commercial preparations. Each experiment was conducted for 24 h. It was shown that, regardless of the active compound used, an increase in drug transport through the skin was observed with RMF exposure. Furthermore, the release profiles depended on the active substance used. Exposure to a rotating magnetic field has been shown to effectively increase the permeability of an active substance through the skin. [ABSTRACT FROM AUTHOR]