Back to Search
Start Over
Conditioned catalepsy vs. Increase in locomotor activity induced by haloperidol.
- Source :
-
Neuroscience Letters . Apr2023, Vol. 802, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- • Haloperidol induces both conditioned catalepsy and increased spontaneous activity. • Type and time of testing determines the nature of the apparently opposed conditioned responses. • Changes in behaviour could be the result of conditioned changes in dopaminergic activity. Previous research has revealed a high degree of complexity of the conditioned response that appears after associating a context with the effects of the dopaminergic antagonist haloperidol. Specifically, when a drug-free test is performed in the presence of the context, conditioned catalepsy is observed. However, if the test is extended over time, the opposite effect occurs, namely, a conditioned increase in locomotor activity. In this paper, we present the results of an experiment with rats that received repeated administration of haloperidol or saline before or after exposure to the context. Next, a drug-free test was performed to evaluate catalepsy and spontaneous locomotor activity. The results revealed, on the one hand, the expected conditioned response of catalepsy for those animals that received the drug prior to context exposure during conditioning. However, for the same group, an analysis of locomotor activity for an extended period of ten minutes after registering catalepsy revealed an increase in general activity and more faster movements compared to the control groups. These results are interpreted considering the possible temporal dynamics of the conditioned response that could induce changes in dopaminergic transmission responsible for the observed changes in locomotor activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CONDITIONED response
*HALOPERIDOL
*CONFORMANCE testing
*CLASSICAL conditioning
Subjects
Details
- Language :
- English
- ISSN :
- 03043940
- Volume :
- 802
- Database :
- Academic Search Index
- Journal :
- Neuroscience Letters
- Publication Type :
- Academic Journal
- Accession number :
- 162592482
- Full Text :
- https://doi.org/10.1016/j.neulet.2023.137174