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A Tasquinomod-loaded dopaminemodified pH sensitive hydrogel is effective at inhibiting the proliferation of KRAS mutant lung cancer cells.
- Source :
-
Journal of Applied Biomaterials & Functional Materials . Jan-Dec2022, Vol. 20, p1-8. 8p. - Publication Year :
- 2022
-
Abstract
- Hydrogels can maintain a high local drug concentration during treatments and may be useful to local targeting diseased areas. We propose a pH sensitive hydrogel consisting of poly-vinylpyrrolidone (PVP) and chitosan as a new treatment method for KRAS mutant lung cancer. Addition of dopamine improved the drug loading and release effects of this hydrogel. We demonstrate that Tasquinimod-loading of this dopamine-modified pH sensitive hydrogel is more effective than Tasquinimod alone for inhibiting the proliferation of KRAS mutant lung cancer cells. Combination of conventional drugs with hydrogels may thus provide a new treatment modality for lung cancer. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LUNG cancer
*RAS oncogenes
*CANCER cells
*DOPAMINE agents
Subjects
Details
- Language :
- English
- ISSN :
- 22808000
- Volume :
- 20
- Database :
- Academic Search Index
- Journal :
- Journal of Applied Biomaterials & Functional Materials
- Publication Type :
- Academic Journal
- Accession number :
- 162488291
- Full Text :
- https://doi.org/10.1177/22808000211073729