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New method for the synthesis of thieno[2,3-d]pyrimidines.
- Source :
-
Chemistry of Heterocyclic Compounds . Oct2004, Vol. 40 Issue 10, p1352-1358. 7p. - Publication Year :
- 2004
-
Abstract
- The reaction of 5-formyl-4-thiocyanatopyrimidines with nitromethane was studied under various conditions. The reaction was found unexpectedly to proceed with closure of a thiophene ring to give thieno[2,3-d]pyrimidines. The use of ammonium acetate as the catalyst leads to a side reaction involving closure of an isothiazole ring to give isothiazolo[5,4-d]pyrimidines. X-ray diffraction crystallographic analysis was used to confirm the structure of thieno[2,3-d]pyrimidine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093122
- Volume :
- 40
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Chemistry of Heterocyclic Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 16243690
- Full Text :
- https://doi.org/10.1007/s10593-005-0082-y