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Antibiotic resistance in ocular bacterial infections: an integrative review of ophthalmic chloramphenicol.
- Source :
-
Tropical Medicine & Health . 3/9/2023, Vol. 51 Issue 1, p1-10. 10p. - Publication Year :
- 2023
-
Abstract
- Introduction: Chloramphenicol is a broad-spectrum antibiotic widely used for treating ophthalmic infections, but concerns about rising bacterial resistance to chloramphenicol have been observed due to its frequent use as an over-the-counter medication. This review assessed the common ophthalmic bacterial pathogens, their chloramphenicol resistance mechanisms, and rates of drug resistance. Methods: PubMed and Google Scholar databases were searched for relevant publications from the years 2000 to 2022, bordering on ophthalmic bacterial infections, chloramphenicol susceptibility profiles, and drug resistance mechanisms against chloramphenicol. A total of 53 journal publications met the inclusion criteria, with data on the antibiotic susceptibility profiles available in 44 of the reviewed studies, which were extracted and analyzed. Results: The mean resistance rates to chloramphenicol from antibiotic susceptibility profiles varied between 0% and 74.1%, with the majority of the studies (86.4%) showing chloramphenicol resistance rates below 50%, and more than half (23 out of 44) of the studies showed resistance rates lower than 20%. The majority of the publications (n = 27; 61.4%) were from developed nations, compared to developing nations (n = 14; 31.8%), while a fraction (n = 3; 6.8%) of the studies were regional cohort studies in Europe, with no country-specific drug resistance rates. No pattern of cumulative increase or decrease in ophthalmic bacterial resistance to chloramphenicol was observed. Conclusions: Chloramphenicol is still active against ophthalmic bacterial infections and is suitable as a topical antibiotic for ophthalmic infections. However, concerns remain about the drug becoming unsuitable in the long run due to some proof of high drug resistance rates. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13488945
- Volume :
- 51
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Tropical Medicine & Health
- Publication Type :
- Academic Journal
- Accession number :
- 162322387
- Full Text :
- https://doi.org/10.1186/s41182-023-00496-x