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Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor hypofunction.

Modulation of circuit oscillations in the rat anterior cingulate cortex (ACC) in vitro by mGlu2 metabotropic glutamate receptors and alleviation of the effects of phencyclidine-induced NMDA-receptor hypofunction.

Authors :
Dennis, Bethany H.
Neale, Stuart A.
LeBeau, Fiona E.N.
Salt, Thomas E.
Source :
Pharmacology, Biochemistry & Behavior. Feb2023, Vol. 223, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Aberrant cortical oscillations in the beta and gamma range are associated with symptoms of schizophrenia and other psychiatric conditions. We have thus investigated the ability of anterior cingulate cortex (ACC) in vitro to generate beta and gamma oscillations, and how these are affected by Group II metabotropic glutamate (mGlu) receptor activation and blockade of N -methyl- d -aspartate (NMDA) receptors. Activation of Group II mGlu receptors, and mGlu2 specifically, with orthosteric agonists reduced the power of both beta and gamma oscillations in ACC without a significant effect on oscillation peak frequencies. The NMDA receptor blocker phencyclidine (PCP), known to evoke certain schizophrenia-like symptoms in humans, elevated the power of beta oscillations in ACC and caused a shift in oscillation frequency from the gamma range to the beta range. These enhanced beta oscillations were reduced by the Group II mGlu receptor agonists. These results show that Group II mGlu receptors, and specifically mGlu2, modulate network oscillations. Furthermore, attenuation of the effect of PCP suggests that mGlu2 receptors may stabilise aberrant network activity. These results underline the importance of Group II mGlu receptors, and particularly mGlu2, as targets for the treatment of neuropsychiatric and neurodegenerative diseases. • Rat anterior cingulate cortex shows kainate-induced beta and gamma frequency oscillations in vitro. • Group II metabotropic glutamate (mGlu2 and mGlu3) receptors modulate these oscillations. • The NMDA antagonist phencyclidine (PCP) induces a significant increase in beta frequency oscillations. • The PCP effect is attenuated by activation of mGlu2 receptors. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00913057
Volume :
223
Database :
Academic Search Index
Journal :
Pharmacology, Biochemistry & Behavior
Publication Type :
Academic Journal
Accession number :
162286670
Full Text :
https://doi.org/10.1016/j.pbb.2023.173532