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Mutual interaction of lncRNAs and epigenetics: focusing on cancer.

Authors :
Ranjbar, Maryam
Heydarzadeh, Samaneh
Shekari Khaniani, Mahmoud
Foruzandeh, Zahra
Seif, Farhad
Pornour, Majid
Rahmanpour, Dara
Tarhriz, Vahideh
Alivand, MohammadReza
Source :
Egyptian Journal of Medical Human Genetics. 3/6/2023, Vol. 24 Issue 1, p1-14. 14p.
Publication Year :
2023

Abstract

Long noncoding RNAs are characterized as noncoding transcripts longer than 200 nucleotides in response to a variety of functions within the cells. They are involved in almost all cellular mechanisms so as epigenetics. Given that epigenetics is an important phenomenon, which participates in the biology of complex diseases, many valuable studies have been performed to demonstrate the control status of lncRNAs and epigenetics. DNA methylation and histone modifications as epigenetic mechanisms can regulate the expression of lncRNAs by affecting their coding genes. Reciprocally, the three-dimensional structure of lncRNAs could mechanistically control the activity of epigenetic-related enzymes. Dysregulation in the mutual interaction between epigenetics and lncRNAs is one of the hallmarks of cancer. These mechanisms are either directly or indirectly involved in various cancer properties such as proliferation, apoptosis, invasion, and metastasis. For instance, lncRNA HOTAIR plays a role in regulating the expression of many genes by interacting with epigenetic factors such as DNA methyltransferases and EZH2, and thus plays a role in the initiation and progression of various cancers. Conversely, the expression of this lncRNA is also controlled by epigenetic factors. Therefore, focusing on this reciprocated interaction can apply to cancer management and the identification of prognostic, diagnostic, and druggable targets. In the current review, we discuss the reciprocal relationship between lncRNAs and epigenetic mechanisms to promote or prevent cancer progression and find new potent biomarkers and targets for cancer diagnosis and therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11108630
Volume :
24
Issue :
1
Database :
Academic Search Index
Journal :
Egyptian Journal of Medical Human Genetics
Publication Type :
Academic Journal
Accession number :
162232866
Full Text :
https://doi.org/10.1186/s43042-023-00404-2