EEG frontal lobe asymmetry as a function of sex, depression severity, and depression subtype.

To investigate possible contributors to the inconsistent association between frontal lobe asymmetry (FLA) and depression, EEG data were collected across five frontal sites, and examined for their associations with four subtypes of depression (Depressed mood, Anhedonia, Cognitive depression, Somatic depression). One hundred community volunteers (54 males, 46 females) aged at least 18 yr completed standardized scales for depression and anxiety, and gave EEG data under Eyes Open and Eyes Closed conditions. Results indicated that, although there was no significant correlation between the differences in EEG power across each of the five pairs of frontal sites and total depression scores, there were several meaningful correlations (accounting for at least 10% of the variance) between specific EEG site differences data and each of the four depression subtypes. There were also different patterns of association between FLA and the depression subtypes according to sex, and total depression severity. These findings help to explain the apparent inconsistency in previous FLA-depression results, and argue for a more nuanced approach to this hypothesis. [Display omitted] • Frontal lobe asymmetry has been inconsistently associated with depression. • Although often measured as a single metric, depression is heterogeneous. • Frontal asymmetry was examined for four subtypes of depression. • Different frontal sites were associated with different depression subtypes. • Asymmetry-depression association was influenced by sex and depression severity. [ABSTRACT FROM AUTHOR]