A new insight into the histogenesis and morphogenesis of Warthin tumour: significance of intranodal excretory duct inclusions.

Overall, the immunophenotype of SIs in the transitional area was identical to that of excretory ducts (Supporting information, S1).[[4]] There were approximately 13 excretory duct-, 6 striated duct- and 5 intercalated duct-type SIs in the lymphoid stroma of WT and 12 excretory duct-, 1 striated duct- and 8 intercalated duct-type SIs in the peritumoral lymph node. Intercalated duct- or striated duct-type SIs were minor components of SIs in the lymphoid stroma of WT and a peritumoral lymph node. In summary, the present WT may have an origin from excretory duct-type SIs in the lymphoid stroma, implying that striated ducts are not essential for the histogenesis and morphogenesis of WT. [Extracted from the article]