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Association between disease‐modifying antirheumatic drugs and bone turnover biomarkers.
- Source :
-
International Journal of Rheumatic Diseases . Mar2023, Vol. 26 Issue 3, p437-445. 9p. - Publication Year :
- 2023
-
Abstract
- Rheumatoid arthritis (RA) has been linked to an increased risk of osteoporosis as well as fractures. Patients diagnosed with RA had a 25% increased risk of osteoporotic fracture, according to a recent population‐based cohort study that compared them to people without RA. Several studies have found a correlation between osteoporosis and the presence of pro‐inflammatory cytokines, such as tumor necrosis factor (TNF)‐α, interleukin (IL)‐1, and 6. These cytokines play a crucial part in the process of bone resorption by boosting osteoclast activation and encouraging osteoclast differentiation. Based on the correlation between RA, osteoporosis, and inflammation, it is possible that systemic immunosuppression with disease‐modifying antirheumatic drugs (DMARDs) can help individuals with RA have a lower chance of developing osteoporosis and osteoporotic fractures. There is little information on how different DMARDs, biologic or non‐biologic, affect RA patients' bone metabolism. In this study, we present an overview of the influence that targeted therapies, such as biologics, non‐biologics, and small molecule inhibitors, have on bone homeostasis in RA patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17561841
- Volume :
- 26
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Rheumatic Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 162203144
- Full Text :
- https://doi.org/10.1111/1756-185X.14550