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Genistein carbon dots exhibit antioxidant and anti-inflammatory effects in vitro.
- Source :
-
Colloids & Surfaces B: Biointerfaces . Mar2023, Vol. 223, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Genistein, an isoflavone from soybean, has attracted attention due to its health benefits, particularly antioxidant and anti-inflammatory activities. Clinical applications of genistein, however, have been limited due to the considerable hydrophobicity and lower bioavailability of the molecule. In this study, carbon dots (C-dots) synthesized from genistein as the carbonaceous precursor exhibit antioxidant properties in test-tube and cell experiments. Anti-inflammatory activity of the genistein-C-dots was also recorded in LPS stimulated macrophages, manifested in inhibition of pro-inflammatory cytokine levels and enhancement anti-inflammatory cytokine expression. The antioxidant and anti-inflammatory effects of the genistein-C-dots, particularly in comparison to the parent genistein molecules, likely account to the display of functional genistein residues on the C-dots' surfaces, and low band gap energy facilitating electron scavenging. Importantly, the genistein-C-dots featured biocompatibility and low cytotoxicity, underlining their potential as a therapeutic vehicle against inflammatory conditions. [Display omitted] • C-dots from genistein retain "structural memory" of the genistein precursor. • Genistein-C-dots exhibit antioxidant effect both in test-tube assays and in-vitro. • Genistein-C-dots treatment had pronounced anti-inflammatory effects in LPS stimulated RAW 264.7 macrophages. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENISTEIN
*BAND gaps
*ANTIOXIDANTS
*ANTI-inflammatory agents
*ENERGY bands
Subjects
Details
- Language :
- English
- ISSN :
- 09277765
- Volume :
- 223
- Database :
- Academic Search Index
- Journal :
- Colloids & Surfaces B: Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 162178659
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2023.113173