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Sensbio: an online server for biosensor design.
- Source :
-
BMC Bioinformatics . 2/28/2023, Vol. 24 Issue 1, p1-15. 15p. - Publication Year :
- 2023
-
Abstract
- Allosteric transcription factor (aTF) based biosensors can be used to engineer genetic circuits for a wide range of applications. The literature and online databases contain hundreds of experimentally validated molecule-TF pairs; however, the knowledge is scattered and often incomplete. Additionally, compared to the number of compounds that can be produced in living systems, those with known associated TF-compound interactions are low. For these reasons, new tools that help researchers find new possible TF-ligand pairs are called for. In this work, we present Sensbio, a computational tool that through similarity comparison against a TF-ligand reference database, is able to identify putative transcription factors that can be activated by a given input molecule. In addition to the collection of algorithms, an online application has also been developed, together with a predictive model created to find new possible matches based on machine learning. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14712105
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Bioinformatics
- Publication Type :
- Academic Journal
- Accession number :
- 162138517
- Full Text :
- https://doi.org/10.1186/s12859-023-05201-7