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What Role do Androgens Play in Endometrial Cancer?
- Source :
-
Journal of Personalized Medicine . Feb2023, Vol. 13 Issue 2, p341. 10p. - Publication Year :
- 2023
-
Abstract
- The role of estrogens and progesterone in the development and progression of endometrial cancer is well-established, but there are very little data about the role of androgens. There are five different androgens produced in women: dehydroepiandrosterone sulphate (DHEAS), dehydroepiandrosterone (DHEA), androstenedione (A4), testosterone (T) and dihydrotestosterone (DHT). The most potent hormones are T and DHT, the latter being mainly produced from T in peripheral tissues, including endometrium. Although they are considered to exert antiproliferative effects in many settings and the expression of their receptors is more often associated with a good prognosis in EC, it is still unknown in which specific settings androgens have carcinogenic or protective effects in EC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20754426
- Volume :
- 13
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Personalized Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 162133874
- Full Text :
- https://doi.org/10.3390/jpm13020341