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Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction.

Authors :
Rabaan, Ali A.
AlSaihati, Hajir
Bukhamsin, Rehab
Bakhrebah, Muhammed A.
Nassar, Majed S.
Alsaleh, Abdulmonem A.
Alhashem, Yousef N.
Bukhamseen, Ammar Y.
Al-Ruhimy, Khalil
Alotaibi, Mohammed
Alsubki, Roua A.
Alahmed, Hejji E.
Al-Abdulhadi, Saleh
Alhashem, Fatemah A.
Alqatari, Ahlam A.
Alsayyah, Ahmed
Farahat, Ramadan Abdelmoez
Abdulal, Rwaa H.
Al-Ahmed, Ali H.
Imran, Mohd.
Source :
Current Oncology. Feb2023, Vol. 30 Issue 2, p1954-1976. 23p. 3 Diagrams, 5 Charts.
Publication Year :
2023

Abstract

Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11980052
Volume :
30
Issue :
2
Database :
Academic Search Index
Journal :
Current Oncology
Publication Type :
Academic Journal
Accession number :
162118306
Full Text :
https://doi.org/10.3390/curroncol30020152