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Stability of vancomycin hydrochloride employed in antimicrobial seal solutions of central intravenous catheters.
- Source :
-
Revista Latino-Americana de Enfermagem (RLAE) . 2022, Vol. 30, p1-11. 11p. - Publication Year :
- 2022
-
Abstract
- Objective: to verify the stability of vancomycin hydrochloride in antimicrobial seal solutions with and without association of heparin sodium according to temperature and association time. Method: an experimental study designed for the analysis of hydrogenionic potential and concentration by means of high-efficiency liquid chromatography of vancomycin hydrochloride (n=06) and vancomycin hydrochloride and heparin sodium (n=06). The solutions studied were submitted to absence of light, as well as to 22°C and 37°C. Analyses in triplicate (n=192) were performed at the initial moment (T0) and three (T3), eight (T8) and 24 hours (T24) after preparation. The data were submitted to analysis of variance (p≤0.05). Results: concentration of the antimicrobial at 22°C presented a reduction (T0-T8) and a subsequent increase (T24); hydrogenionic potential decreased significantly over time. At 37°C, the concentration increased up to T3 and decreased at T24, with a reduction of hydrogenionic potential up to 24 hours. Concentration of the vancomycin hydrochloride and heparin sodium solutions varied with a reduction at 22°C, accompanied by increased hydrogenionic potential. Precipitate formation was observed by visual inspection of the vancomycin hydrochloride-heparin sodium association (T3). Conclusion: pharmacological stability of vancomycin hydrochloride (5 mg/mL) and physical incompatibility with heparin sodium (100 IU/mL) were evidenced after three hours of association in the antimicrobial seal solutions studied. [ABSTRACT FROM AUTHOR]
- Subjects :
- *EXPERIMENTAL design
*CATHETER-related infections
*TEMPERATURE
*HIGH performance liquid chromatography
*INTRAVENOUS therapy
*PHARMACOLOGY
*VANCOMYCIN
*LABORATORIES
*MEDICAL protocols
*DRUG stability
*DRUG interactions
*DESCRIPTIVE statistics
*SOLUTION (Chemistry)
*HEPARIN
*CENTRAL venous catheters
*MICROBIAL contamination
*DOSAGE forms of drugs
Subjects
Details
- Language :
- English
- ISSN :
- 15188345
- Volume :
- 30
- Database :
- Academic Search Index
- Journal :
- Revista Latino-Americana de Enfermagem (RLAE)
- Publication Type :
- Academic Journal
- Accession number :
- 162047932
- Full Text :
- https://doi.org/10.1590/1518.8345.5869.3621