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Neonatal lupus erythematosus - prevention is better than cure.
- Source :
-
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii . Dec2022, Vol. 39 Issue 6, p1021-1026. 6p. - Publication Year :
- 2022
-
Abstract
- Neonatal lupus erythematosus (NLE) is a congenital autoimmune condition in which the transplacental passage of immunoglobulin G (IgG) directed against auto-antigens causes clinical symptoms in the foetus or neonate. Anti-Ro/SS-A, anti-La/SS-B, and to a lesser extent, anti-U1RNP autoantibodies (aAbs) have the strongest association with NLE. However, ~ 50% of affected mothers are asymptomatic despite carrying those aAbs. The clinical picture of the disease is very diverse. Cardiac manifestations are the most severe, including congenital heart block (CHB), with a mortality rate of ~18%. Preventative therapy with hydroxychloroquine (HCQ) reduces the recurrence rate of CHB in subsequent pregnancies by ~50%. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AUTOANTIBODIES
*OPERATIVE surgery
*MORTALITY
*HYDROXYCHLOROQUINE
*NEWBORN infants
Subjects
Details
- Language :
- English
- ISSN :
- 1642395X
- Volume :
- 39
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii
- Publication Type :
- Academic Journal
- Accession number :
- 162041233
- Full Text :
- https://doi.org/10.5114/ada.2022.122601