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Bone status and HCV infection in thalassemia major patients.

Authors :
Meloni, Antonella
Pistoia, Laura
Maffei, Silvia
Ricchi, Paolo
Casini, Tommaso
Corigliano, Elisabetta
Putti, Maria Caterina
Cuccia, Liana
Argento, Crocetta
Positano, Vincenzo
Pepe, Alessia
Cademartiri, Filippo
Vassalle, Cristina
Source :
BONE. Apr2023, Vol. 169, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Hepatitis C virus (HCV) infection increases the risk for osteoporosis but this relationship has not been investigated among multi-transfused patients with thalassemia major (TM). We cross-sectionally explored the association of HCV infection with bone mineral density (BMD), vitamin D, and bone turnover biomarkers in TM. We considered 130 TM patients (41.89 ± 5.49 years, 67 females) enrolled in the E -MIOT (Extension-Myocardial Iron Overload in Thalassemia) Network. BMD measurements taken at the lumbar spine, femoral neck and total hip were expressed as Z -scores, with a BMD Z-score ≤ −2.0 indicating low bone mass. Z-scores were not associated with gender, iron overload indices, vitamin D levels, and biochemical bone turnover markers, but decreased with aging and in presence of hypogonadism and were directly correlated with body mass index (BMI). The prevalence of low bone mass was 70.7 %. Three groups of patients were identified: 78 who never contracted the infection (group 0), 72 who cleared HCV (group 1), and 29 with chronic HCV infection (CHC) (group 2). All Z -scores progressively decreased according to HCV status from group 0 to group 2. Osteocalcin levels were significantly lower in groups 2 and 1 than in group 0. CHC patients were more likely to have low bone mass compared to HCV naive patients, after adjusting for age, BMI, hypogonadism, and pancreatic iron. In TM, CHC appears as one additive risk factor for low bone mass and osteocalcin may play a role in this association. • In TM, lower BMD Z -scores are associated with hypogonadism and pancreatic iron load. • In TM, HCV represents an independent risk factor for low bone mineral density. • Osteocalcin may play a role in the loss of bone mass associated with HCV infection. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
87563282
Volume :
169
Database :
Academic Search Index
Journal :
BONE
Publication Type :
Academic Journal
Accession number :
162009910
Full Text :
https://doi.org/10.1016/j.bone.2023.116671