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High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study.

High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study.

Authors :
Laway, Bashir Ahmad
Rasool, Abid
Baba, Mohammad Salem
Misgar, Raiz Ahmad
Bashir, Mir Iftikhar
Wani, Arshad Iqbal
Choh, Naseer
Shah, Omair
Lone, Ajaz
Shah, Zaffar
Source :
Clinical Endocrinology. Mar2023, Vol. 98 Issue 3, p375-382. 8p.
Publication Year :
2023

Abstract

Objective: Patients with Sheehan syndrome (SS) are predisposed to coronary artery disease (CAD) due to risk factors like abdominal obesity, dyslipidemia and chronic inflammation. In addition to estimate CAD risk enhancers like high sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and lipoprotein A [Lp(a)], this study applies Framingham risk score (FRS) and coronary artery calcium (CAC) score to compute a 10‐year probability of cardiovascular (CV) events in SS patients. Design: Case–control study Sixty‐three SS patients, on a stable hormonal replacement treatment except for growth hormone and 65 age, body mass index and parity‐matched controls. Measurements: Measurement of serum hsCRP, ApoB and Lp(a) and estimation of CAC with 16‐row multislice computed tomography scanner. Results: The concentrations of hsCRP, ApoB and Lp(a) were significantly higher in SS patients than in controls (p <.01). After calculating FRS, 95.2% of SS patients were classified as low risk, 4.8% as intermediate risk and all controls were classified as low risk for probable CV events. CAC was detected in 50.7% SS patients and 7.6% controls (p =.006). According to the CAC score, 26.9% SS patients were classified as at risk (CAC > 10) for incident CV events as against 1.6% controls. The mean Multi‐Ethnic Study of Atherosclerosis (MESA) score was significantly higher in patients with SS than controls. CAC corelated significantly with fasting blood glucose (r =.316), ApoB (r =.549), LP(a) (r =.310) and FRS (r =.294). Conclusion: Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03000664
Volume :
98
Issue :
3
Database :
Academic Search Index
Journal :
Clinical Endocrinology
Publication Type :
Academic Journal
Accession number :
161968076
Full Text :
https://doi.org/10.1111/cen.14871