氢质子磁共振波谱用于帕金森病早期诊断的价值研究.

Objective To explore the clinical value of Hydrogen proton magnetic resonance spectroscopy (¹H-MRS) in the early diagnosis of Parkinson's disease (PD). Methods A total of 45 patients with early PD (PD group) and 40 healthy volunteers (control group) admitted to the Outpatient and Inpatient Departments of Yancheng First People's Hospital from May 2017 to May 2020 were selected as the research subjects. All subjects were examined by ¹H-MRS, and the ratios of N-acetylaspartic acid (NAA)/choline (Cho), NAA/creatine (Cr) and Cho/Cr in lentiform nucleus, globus pallidus, thalamus and substantia nigra of all subjects were compared and analyzed. Results The ratios of NAA/Cho, NAA/Cr in lenticular nucleus, globus pallidus and substantia nigra, and the ratios of NAA/Cho, NAA/Cr and Cho/Cr of the thalamus in the PD group were significantly lower than those in the control group, and the differences were statistically significant (P<0. 05). In the PD group, the ratios of NAA/Cho and NAA/Cr in lenticular nucleus, globus pallidus and substantia nigra, as well as the ratios of NAA/Cho, NAA/Cr and Cho/Cr in thalamus were negatively correlated with the Unified Parkinson's Disease Rating Scale (UPDRS) scores (P <0. 05). The area under curve (AUC) of the receiver operating characteristic curve of the NAA/Cho ratio in the lenticular nucleus, globus pallidus, thalamus 'and substantia nigra was 0. 796,0. 708, 0. 709 and 0. 723, respectively. The AUC of the NAA/Cr ratio was 0. 726,0. 726,0. 744 and 0. 913, respectively. The AUC of the Cho/Cr ratio was 0. 579, 0. 509,0. 637 and 0. 531, respectively. Conclusion It can be combined with' H-MRS on the peak changes of NAA, Cho and Cr in the lenticular nucleus, globus pallidus, thalamus and substantia nigra and the changes in the ratio of the three to diagnose early PD. ' H-MRS may have good diagnostic value for early PD. [ABSTRACT FROM AUTHOR]