Transformable "Tubulin Traps" Interfere with Mitochondrial Autophagy and Promote the Elimination of Glioblastoma.

Protective autophagy of mitochondria is an important cause of high mortality in glioblastoma (GBM). Because of its serious impact on the treatment effect, it is in urgent need of combined treatment. Based on the regulatory function of the tubulin system on autophagy and inspired by the natural characteristics of neurofilament regulating tubulin polymerization, an in situ self‐assembled "tubulin trap" is designed. Specifically, the system is a transformable block polymer, which can self‐assemble into spherical nanoparticles in water. After targeting GBM cells, they can transform into nanofibers under the intracellular GSH conditions, interfering with autophagy. The research shows that, in mouse GBM xenograft models, the transformable nanofibers with the function of destroying tubulin homeostasis can be combined with ceramide in the treatment of GBM. [ABSTRACT FROM AUTHOR]