Ischemia-modified albumin levels are elevated, and thiol/disulfite homeostasis is impaired in Behçet's disease.

Objective: To investigate the relationship between Behçet's disease (BD) and ischemia-modified albumin (IMA) and thiol molecules and to evaluate serum levels of this molecule in complications that may develop due to BD. BD is a vasculitic disease characterized by recurrent oral starring scarring genital ulcerated lesions and triple complex symptoms of uveitis, histopathologically involving perivascular tissues and vascular wall. It is thought that the mechanism responsible for vascular damage may be immunoregulatory system dysregulation and increased oxidative stress. In this study, serum levels of IMA and native thiol (-SH), total thiol (-SS+-SH), disulfide (-SS) were evaluated in BD and different clinical presentations of the disease. Methods: Thirty-nine Behçet's patients and 40 healthy volunteers were included in the study. IMA, -SH, and -SS levels were measured using the spectrophotometric (Sigma-Aldrich Chemie GmbH Riedstrasse 2, Steinheim, Germany) method. Statistical analysis were performed using the SPSS version 21.0 package program. Results: In our study, the mean IMA (p<0.001), -SS/-SH (p<0.01), and -SS/(-SS + -SH) ratios (p<0.01) were found to be significantly higher in Behçet's patients compared to the control group. In receiver operating characteristic (ROC) analysis, the highest associated value with BD was found in IMA (p:0.001, AUC:0.713). In BD, no significant difference was found between those with mucocutaneous involvement and those with organ involvement in terms of IMA and thiol/disulfide parameters (p>0.05). Conclusion: In our study, we found that IMA serum levels were high, and -SS/-SH and -SS/(-SS + -SH) ratios were significantly low in BD. [ABSTRACT FROM AUTHOR]