记忆训练联合电针疗法对全脑放疗患者认知功能、健康相关生命质量 和颅脑磁共振灌注成像参数的影响.

Objective: To investigate the effects of memory training combined with electroacupuncture therapy on cognitive function, health-related quality of life and brain magnetic resonance perfusion imaging parameters in patients with whole brain radiotherapy. Methods: 94 patients with whole brain radiotherapy who were treated in Affiliated Hospital of Jiangnan University from March 2020 to January 2022 were selected, and they were randomly divided into the study group (routine intervention, memory training combined with electroacupuncture therapy) and the control group (routine intervention), 47 cases each. The changes of cognitive function, health-related quality of life and brain magnetic resonance perfusion imaging parameters were compared between the two groups. Results: 1 week, 2 weeks, 3 week and 4 weeks after treatment, the scores of Montreal Cognitive Function Scale (MoCA) and Mini-Mental State Examination (MMSE) in two groups decreased gradually compared with those before treatment, but the scores of MoCA and MMSE in the study group at each time point were higher than those in the control group (P<0.05). 4 weeks after treatment, the scores and total scores of all dimensions of the health-related quality of life scale (HRQoL) in two groups were higher than those before treatment, and the above scores in the study group were higher than those in the control group (P<0.05). 4 weeks after treatment, mean cerebral blood volume (CBV) and mean cerebral blood flow (CBF) in two groups were decreased compared with those before treatment, but those in the study group were higher than those in the control group (P<0.05). Conclusion: Memory training combined with electroacupuncture therapy can alleviate the cognitive impairment caused by whole brain radiotherapy and improve the health-related quality of life of patients, which may be related to the regulation of cerebral blood volume and cerebral blood flow. [ABSTRACT FROM AUTHOR]