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Monoterpenoid derivatives from Hyssopus cuspidatus Boriss. and their bioactivities.
- Source :
-
Fitoterapia . Mar2023, Vol. 165, pN.PAG-N.PAG. 1p. - Publication Year :
- 2023
-
Abstract
- Six undescribed monoterpenoids, together with twelve known compounds were isolated and identified from Hyssopus cuspidatus Boriss. Their structures were established by spectroscopic analysis, and the absolute configurations were established by ECD calculations and single-crystal X-ray diffraction crystallography. The isolated compounds were tested for their anti-inflammatory, antibacterial and antitumor activities. Most of the compounds showed potent anti-inflammatory activities. Among them, 3 β -hydroxy-7,8-dihydro- β -ionone (8), oleanolic acid (17) and acetylpleamolic acid (18) showed strong anti-inflammatory activity against IL-6 and TNF- α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells. Several compounds showed moderate inhibitory activities against Staphylococcus aureus , Candida albicans , and Escherichia coli. And (4 S)- p -menth-l-ene-7,8-diol 8- O - β -D-glucopyranoside (16) showed antitumor activities against MCF-8 and HT-29 cell lines with IC 50 values of 93.39 ± 3.69 and 71.89 ± 2.94 μ M, respectively. Oleanolic acid (17) showed moderate antitumor activity against HT-29 cell lines with an IC 50 value of 52.62 ± 1.63 μ M. In this study, the discovery of anti-inflammatory, antibacterial and antitumor components from H. cuspidatus could benefit further development and utilization of this plant. [Display omitted] • Eighteen terpenoids including six new ones were isolated from Hyssopus cuspidatus. • Most of the compounds showed potent anti-inflammatory activities. • Compound 8 showed strong anti-inflammatory activity against IL-6 and TNF-α. • Several compounds showed good activities against MCF-8, HT-29 and HT-29 cell lines. • Several compounds showed moderate antimicrobial activities. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKINS
*LIPOPOLYSACCHARIDES
*ESCHERICHIA coli
*MEDICINAL plants
*TERPENES
*ANTI-inflammatory agents
*STEROIDS
*ANTINEOPLASTIC agents
*PLANTS
*CRYSTALLOGRAPHY
*TUMOR necrosis factors
*STAPHYLOCOCCUS aureus
*DESCRIPTIVE statistics
*PLANT extracts
*MOLECULAR structure
*CELL lines
*CANDIDA albicans
*ANTIBIOTICS
*SPECTRUM analysis
*PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 165
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 161729714
- Full Text :
- https://doi.org/10.1016/j.fitote.2023.105432