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Three new fumagillol analogues and antifungal activity from Aspergillus fumigatus cocultured with Paraphaeosphaeria sp.

Authors :
Su, Shuang
Yang, Xue-Qiong
Yang, Ya-Bin
Ding, Zhong-Tao
Source :
Fitoterapia. Mar2023, Vol. 165, pN.PAG-N.PAG. 1p.
Publication Year :
2023

Abstract

Two fungi Aspergillus fumigatus YXG-12-2, and Paraphaeosphaeria sp. YXG-18 were isolated from medicinal plant Ginkgo biloba. The interaction of endophytes and host could induce the productions of antifungal metabolites against pathogens for the plant resistance. Three new fumagillol analogues, fumiparaphines A-C were isolated from A. fumigatus cocultured with Paraphaeosphaeria sp. in host medium. New compounds 2 , and 3 had the similar fumagillol structures with tetrahydrofuran or tetrahydropyrane residue. The structures were established by 1D, 2D NMR, mass spectrometry, and calculated ECD spectra. Fumiparaphine A (1) indicated significant antifungal activity against the phytopathogen Alternaria alternata with MIC of 2 μg/mL. [Display omitted] [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0367326X
Volume :
165
Database :
Academic Search Index
Journal :
Fitoterapia
Publication Type :
Academic Journal
Accession number :
161729688
Full Text :
https://doi.org/10.1016/j.fitote.2022.105395