Tranexamic acid in total knee arthroplasty.

The authors found a dose-dependent surgical site infection risk in blood-transfused patients and hypothesised that those undergoing knee arthroplasty who receive multiple doses of TXA, but still required red cell transfusions, tended to be more susceptible to infection. Whilst Ling et al. [[13]] found that the combination of intravenous and intra-articular TXA was more efficacious than either alone, this is doubtless because there is a dose dependent effect of TXA, and 2 g is probably too high a dose to be administered in knee surgery. Even allowing for the increased use of TXA more recently, and other improvements in patient management that invariably occur with time, they found that the administration of TXA was associated with a 38% reduction in blood transfusion and was not associated with an excess incidence of thromboembolic events. Keywords: knee surgery; safety; tranexamic acid EN knee surgery safety tranexamic acid 275 278 4 02/08/23 20230301 NES 230301 When we administer any medication, it should be safe, effective and affordable. [Extracted from the article]