One‐Pot Synthesis of N‐Benzyl/Allyl‐N‐phenyl‐2‐benzothiazolamines from 1‐(2‐Iodophenyl)‐3‐phenylthioureas and Benzyl/Allyl Halides.

A facile method for the copper‐catalyzed synthesis of N‐benzyl‐N‐phenyl‐2‐benzothiazolamines was explored. In the presence of CuI, N‐phenylbenzothiazolamines was in situ generated from substituted 1‐(2‐iodophenyl)‐3‐phenylthioureas, which susequently underwent coupling with benzyl/allyl halides to give the desired N‐benzyl/allyl‐N‐phenyl‐2‐benzothiazolamines fluently in a one‐pot manner. The protocol features easy performance, easily available materials, good yield and broad substrates scope, showing potential synthetic value for the preparation of a variety of biologically or pharmaceutically active compounds. [ABSTRACT FROM AUTHOR]