REPORT OF SOME BASIC L-AMINO-ACID OXIDASES PEPTIDES ISOLATED FROM THE NEOTROPICAL LANSBERG'S HOGNOSE VIPER (Porthidium lansbergii hutmanni) SNAKE VENOM FROM MARGARITA ISLAND (VENEZUELA).

L-amino acid oxidases (SV-LAAOs, EC 1.4.3.2) are flavo-enzymes that catalyse the stereo specific oxidative transamination of L-amino acids to a-keto acids with production of ammonia and hydrogen peroxide (H2O2). These enzymes are widely distributed in many different organisms, including snakes from the Elapidae, Viperidae and Crotalidae families, and present as the major component of many of their venoms. The Lansberg's hognose viper (Porthidium lansbergii hutmanni) (Plh) venom characterization and purification included an arrangement of SDSPAGE and 2D electrophoresis, MALDI TOF/TOF and tandem mass spectrometry (LC-MS/MS). In this work, 8 peptides from SV-LAOOs from Plh snakes were named as PLH1-LAAO, PLH2-LAAO, PLH3-LAAO, PLH4-LAAO, PLH5-LAAO, PLH6-LAAO, PLH7-LAAO and PLH8-LAAO. This paper summarises the physic-chemical properties and structural characteristics of various SV-LAAOs peptides from Plh snake venom. [ABSTRACT FROM AUTHOR]