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Production and characterization of hard-shell capsules from carrageenan-alginate with polyethyleneglycol (PEG) plasticizer as drug carrier.
- Source :
-
AIP Conference Proceedings . 2023, Vol. 2554 Issue 1, p1-12. 12p. - Publication Year :
- 2023
-
Abstract
- Drug delivery carrier is a mechanism used to distribute drugs into the body. Drug delivery carrier which is widely used in drug delivery are capsules. Carrageenan-alginate is a vegetable polymer that is expected to be a substitute for gelatin in making capsules. The purpose of this research is to prepare,and characterize carrageenan-alginate hard-shell capsules with polyethylene glycol plasticizers as drug delivery carrier materials. Hard-shell capsules were made from carrageenan-alginate and PEG copolymers with variations in the volume of 0.5 ml (CAP1), 1.0 ml (CAP2), 1.5 ml (CAP3), and 2.0 ml (CAP4). Hard-shell capsules characterization includes swelling, tensile, dissolution, disintegration, kinetic, Fourier-transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscope (SEM) tests. The hard-shell capsules with the most optimum mechanical properties were CAP3 capsules with % swelling of 413.2%, stress values of 101.4 Mpa, strain values of 0.27, and young modulus of 1297.9 Mpa. Dissolution results showed that the salicylamide drug was distributed 11% in buffer phosphate at the 120th minute. Disintegration results for 37 minutes. FTIR results show there are hydrogen bonds between carrageenan, alginate, and PEG. SEM results showed the hard-shell capsules had a smooth and porous surface morphology and cross-section, which was an average of 4.949 µm. The most linear release kinetic test results using the Higuchi model at pH 6.8 with reaction rate constants of 1.002 M.s−1/2 and R2 = 0.967, so that the Carrageenan-alginate copolymer hard-shell capsules with PEG plasticizers can be used as controlled release drug delivery carriers. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0094243X
- Volume :
- 2554
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- AIP Conference Proceedings
- Publication Type :
- Conference
- Accession number :
- 161528174
- Full Text :
- https://doi.org/10.1063/5.0104028