Switching from membrane disrupting to membrane crossing, an effective strategy in designing antibacterial polypeptide.

The article discusses a research study conducted to develop effective antibacterial agents to induce antimicrobial resistance as drug-resistant bacterial infections cause serious threats to human health. It is noted that host defense peptides (HDPs) are believed as promising candidates in developing antimicrobials owing to its broad-spectrum antibacterial activity and insusceptibility to antimicrobial resistance.