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Gene Targeting in Penicillium chrysogenum: Disruption of the lys2 Gene Leads to Penicillin...

Authors :
Casqueiro, Javier
Gutierrez, Santiago
Source :
Journal of Bacteriology. Feb99, Vol. 181 Issue 4, p1181. 8p. 3 Diagrams, 2 Charts, 3 Graphs.
Publication Year :
1999

Abstract

Focuses on a study which described the targeted disruption of the lys2 gene of Penicillium chrysogenum (P. chrysogenum) and explored the effect of the mutation on penicillin production. Strategies for disruption of lys2 by a single crossing over; Lysine auxotrophs obtained by transformation of P. chrysogenum; Disruption of lys2 by double recombination.

Details

Language :
English
ISSN :
00219193
Volume :
181
Issue :
4
Database :
Academic Search Index
Journal :
Journal of Bacteriology
Publication Type :
Academic Journal
Accession number :
1614963
Full Text :
https://doi.org/10.1128/jb.181.4.1181-1188.1999