Transcriptomic analysis for the retested positive COVID‐19 patients with long‐term persistent SARS‐CoV‐2 but without symptoms in Wuhan.

A new type of COVID-19 patients has been reported (referred as LTPPs) recently, who were retested with positive results after hospital discharge, with long-term persistent SARS-CoV-2 in their bodies, although they were recovered from acute infection with no clinical symptom of COVID-19.[[1]] They pose new challenges to the prevention and treatment of COVID-19, but the underlying mechanism for such a contradictory phenomenon remains uncovered. Identification of hub genes and key pathways associated with bipolar disorder based on weighted gene co-expression network analysis. Importantly, 26 of 38 genes have been reported to be associated with COVID-19, and six ones (IL6, CSF3, MIF, ATF4, HLA-G and LGALS3) have been documented to be potential therapeutic targets for the treatment of COVID-19 (Table 1), indicating the credibility of our screening strategy. [Extracted from the article]