The Effects of RBC Concentration on the Viscoelastic Assessment of Coagulation*.

Keywords: coagulation; red blood cells; viscoelastic assays EN coagulation red blood cells viscoelastic assays 329 331 3 01/27/23 20230201 NES 230201 Blood is a non-Newtonian fluid, a colloidal solution with the partial behavior of a suspension. In this issue of I Critical Care Medicine i , Roh et al (11) have published their investigation into the effects of hemoglobin concentration ([Hb]) on viscoelastic tests performed on the ROTEM (https://www.werfen.com/uk/en/haemostasis-diagnostics/rotem-sigma) and TEG-5000 (https://teg.haemonetics.com/en-gb) platforms. However, the effect of RBC concentration abnormalities (anemia and polycythemia) on viscoelastic tests is less clear, though laboratory investigations to date have suggested an anomalous paradoxical effect on the assays, compared with the clinical state. [Extracted from the article]