The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction.

The article presents the discussion on Telomere dysfunction activates the DNA damage checkpoint to induce a cell cycle arrest. Topics include extended period of time where cells can bypass the arrest and undergo cell division despite the persistence of the initial damage, a process called adaptation to DNA damage; and proposing the Cdc5 orchestrates multiple cell cycle pathways to promote adaptation.